Deferasirox Impurity D

Deferasirox Impurity D, also known as 4-[(5Z)-5-[(E)-2-(2,4-dimethylphenyl)hydrazin-1-ylidene]-2-oxo-1,3-thiazolidin-3-yl]benzoic acid, is a synthetic organic compound that is commonly used as an analytical reference standard in research and development laboratories. This impurity is a byproduct of the manufacturing process of Deferasirox, which is an iron-chelating agent used in the treatment of chronic iron overload conditions such as thalassemia and other blood disorders. Chemically, Deferasirox Impurity D is a thiazolidinone derivative with a benzene ring substituted with a hydrazine group and a carboxylic acid group. It is a yellow to orange crystalline powder that is soluble in organic solvents such as methanol and ethanol but is insoluble in water. In terms of usage, Deferasirox Impurity D is primarily used as a reference standard for the identification and quantification of impurities in Deferasirox drug substance and drug product. It is also used as a starting material for the synthesis of other Deferasirox impurities that may be present in the drug substance. The purity of Deferasirox Impurity D is critical to ensure accurate results in analytical testing, and it is typically analyzed using high-performance liquid chromatography (HPLC) or gas chromatography-mass spectrometry (GC-MS). Overall, Deferasirox Impurity D is an important analytical tool for the quality control and development of Deferasirox drug products, and its chemical properties and usage make it a valuable reference standard in the pharmaceutical industry.