Lifitegrast Impurity 8

Lifitegrast Impurity 8, also known as (5R)-2-oxo-5-phenyl-1,3-oxazolidine-5-carboxylic acid, is a chemical impurity that is commonly found in the synthesis of Lifitegrast, a drug used to treat symptoms of dry eye disease. The usage of Lifitegrast Impurity 8 is important because it can affect the efficacy and safety of the Lifitegrast drug. Therefore, it is important to monitor and control the levels of this impurity during the production process to ensure that the final product is safe and effective for patient use. The chemical information of Lifitegrast Impurity 8 includes its molecular formula of C11H9NO4, with a molecular weight of 223.19 g/mol. It has a melting point of 198-202°C and is soluble in water, ethanol, and dimethyl sulfoxide (DMSO). In terms of its chemical properties, Lifitegrast Impurity 8 is a derivative of oxazolidinone and carboxylic acid. It contains a five-membered oxazolidinone ring, which is important for its biological activity. Overall, Lifitegrast Impurity 8 plays a crucial role in the production of Lifitegrast, and its proper management is essential to ensure the safety and effectiveness of the drug for patients suffering from dry eye disease.