rac-N’-Nitrosonornicotine-d4 1-N-Oxide

Rac-N’-Nitrosonornicotine-d4 1-N-Oxide is a stable isotope labeled analog of N’-Nitrosonornicotine (NNN) and is commonly used in various analytical and research applications. The compound is a derivative of nicotine and is a potent carcinogenic agent that is found in tobacco smoke. It has been shown to induce tumors in experimental animals and has been classified as a Group 1 carcinogen by the International Agency for Research on Cancer. The compound is used in various analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) for the quantification and identification of NNN and its metabolites in biological samples. Rac-N’-Nitrosonornicotine-d4 1-N-Oxide is also used as an internal standard in these techniques to improve the accuracy and precision of the analysis. Chemically, the compound has a molecular formula of C9H8D4N3O2 and a molecular weight of 212.25 g/mol. It is a yellowish powder that is soluble in water and has a melting point of 167-170°C. The compound is stable under normal laboratory conditions and can be stored for extended periods. In conclusion, Rac-N’-Nitrosonornicotine-d4 1-N-Oxide is a useful compound in various analytical and research applications. Its stable isotope labeling and potent carcinogenic properties make it an important tool in the study of tobacco smoke-related diseases and their mechanisms of action.