O-Desmethyl Astemizole
| Product Name | O-Desmethyl Astemizole |
|---|---|
| CAT No. | CS-T-16153 |
| CAS No. | 73736-50-2 |
| Category | Impurities |
| Stock | Enquire |
| Mol. Wt. | 444.6 g/mol |
| Mol. For. | C27H29FN4O |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Canonical Smiles | C1CN(CCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)CCC5=CC=C(C=C5)O |
| InchIKey | LAGYWHSFHIMTPE-UHFFFAOYSA-N |
| Inchl | InChI=1S/C27H29FN4O/c28-22-9-5-21(6-10-22)19-32-26-4-2-1-3-25(26)30-27(32)29-23-14-17-31(18-15-23)16-13-20-7-11-24(33)12-8-20/h1-12,23,33H,13-19H2,(H,29,30) |
| IUPAC | 4-[2-[4-[[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]amino]piperidin-1-yl]ethyl]phenol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
O-Desmethyl Astemizole, also known as desmethylastemizole or DMA, is a metabolite of the second-generation antihistamine drug, Astemizole. It is a chemical compound with the molecular formula C19H22N4O and a molecular weight of 318.4 g/mol. DMA is a potent histamine H1 receptor antagonist and has been shown to have antipruritic and anti-inflammatory properties.
The usage of O-Desmethyl Astemizole is mainly in research and development of new drugs that target histamine receptors. It has been found to have potential therapeutic applications in treating autoimmune diseases, cancer, and neurodegenerative disorders. DMA has shown to have an inhibitory effect on the growth of cancer cells and has been studied for its potential use in cancer treatment.
Chemically, O-Desmethyl Astemizole is a metabolite of Astemizole, which is also a potent H1 receptor antagonist used to treat allergies. Astemizole is metabolized in the liver through a process called N-demethylation, which leads to the formation of DMA. DMA has a higher affinity for H1 receptors than Astemizole, making it a more potent antihistamine drug.
In conclusion, O-Desmethyl Astemizole is a potent histamine H1 receptor antagonist with potential therapeutic applications in treating various diseases. Its usage is mainly in research and development of new drugs targeting histamine receptors. DMA is a metabolite of Astemizole, and it is formed through N-demethylation in the liver. Its chemical properties make it a more potent antihistamine than Astemizole.
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