Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde

Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde is a chemical compound that is primarily used as an angiotensin II receptor antagonist. It is a derivative of losartan, which is a commonly used medication for treating high blood pressure. The addition of the tetrazolyl group to the losartan molecule enhances its binding affinity to the angiotensin II receptor, making it a more potent medication. The chemical formula of Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde is C22H18N6O3. It has a molecular weight of 426.41 g/mol. The compound is a yellow powder that is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol. The mechanism of action of Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde involves blocking the action of the hormone angiotensin II. This hormone is responsible for constricting blood vessels, increasing blood pressure, and stimulating the release of aldosterone, which promotes water and salt retention. By blocking the action of angiotensin II, Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde helps to relax blood vessels, lower blood pressure, and reduce the workload on the heart. In conclusion, Des[2-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde is a potent angiotensin II receptor antagonist that is used for treating high blood pressure. Its chemical structure and mechanism of action make it a valuable medication for managing hypertension and reducing the risk of cardiovascular disease.