N,N,N,N-Tetramethylethylenediamine

N,N,N,N-Tetramethylethylenediamine (TMEDA) is a colorless, organic compound with the chemical formula C6H16N2. This diamine is a popular ligand in coordination chemistry and serves as a powerful base in organic synthesis. TMEDA is a derivative of ethylenediamine, with four methyl groups replacing the four hydrogen atoms of the ethylene backbone. TMEDA is commonly used as a complexing agent in coordination chemistry, particularly in the preparation of transition metal complexes. It can coordinate with metals to form stable chelate complexes, which have applications in catalysis, materials science, and pharmaceuticals. TMEDA also serves as a powerful base in organic synthesis, particularly in the preparation of Grignard reagents. It enhances the reactivity of these reagents, allowing for the synthesis of a wide range of organic compounds. TMEDA is a highly flammable liquid with a strong, amine-like odor. It is soluble in most organic solvents, including water, and has a boiling point of 99-100 °C. It is considered a hazardous substance and should be handled with care due to its flammability and toxicity. When exposed to air, TMEDA can form explosive peroxides. It is important to store TMEDA in a tightly sealed container and to use caution when handling it.