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Ambrisentan D10

Chemical Name Ambrisentan D10
CAT No. CS-T-47593
CAS Registry# 1046116-27-1
Status Under Certification (Usually dispatched in 5 days)
Category Stable Isotopes
Hazardous This is not a Hazardous Compound
COA View Sample COA
Controlled No

Additional Information


Controlled No
Parent API Ambrisentan
Smileys CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
Canonical Smiles CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InchIKey OUJTZYPIHDYQMC-KYBYSFRQSA-N
Inchl InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1/i4D,5D,6D,7D,8D,9D,10D,11D,12D,13D
IUPAC (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-bis(2,3,4,5,6-pentadeuteriophenyl)propanoic acid
Hazardous No


Usage and description


Ambrisentan D10 is a deuterated form of the medication Ambrisentan, which is used to treat pulmonary arterial hypertension (PAH). PAH is a rare but serious condition which causes high blood pressure in the arteries that supply blood to the lungs, making it difficult for the heart to pump blood effectively. Ambrisentan D10 is a selective endothelin receptor antagonist, which means it inhibits the action of endothelin, a hormone that causes constriction of blood vessels. This helps to reduce the high blood pressure in the lungs and improve blood flow, which alleviates the symptoms of PAH. Ambrisentan D10 is administered orally, either as a tablet or a suspension, and is usually taken once a day. The dosage will depend on the severity of the condition and the patient's response to treatment. It is important to take the medication at the same time each day to ensure consistent blood levels. As with any medication, Ambrisentan D10 has potential side effects, including headache, nasal congestion, and flushing. In rare cases, it can cause liver damage, so patients are advised to have regular liver function tests while taking the medication. In terms of chemical information, Ambrisentan D10 has a molecular formula of C22H18D10N5O2 and a molecular weight of 392.54 g/mol. It is a deuterated analog of Ambrisentan, which means it contains a higher proportion of deuterium than the regular medication. This can affect the way the drug is metabolized in the body, potentially leading to differences in efficacy and side effects. However, the clinical significance of these differences is not yet fully understood.

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