Chlorothiazide 13C,15N2

Chlorothiazide 13C,15N2 is a chemical compound that belongs to the class of thiazide diuretics. It is used primarily to treat hypertension (high blood pressure) and edema (swelling) caused by heart failure, liver cirrhosis, and kidney diseases. The drug works by blocking the reabsorption of sodium and chloride ions in the kidneys, leading to increased urine output and decreased fluid retention. Chlorothiazide 13C,15N2 is a stable isotope-labeled version of the drug, which is used for pharmacokinetic studies, metabolic research, and drug discovery. The compound contains two heavy isotopes of carbon (13C) and nitrogen (15N) that can be easily detected and distinguished from the natural isotopes (12C and 14N) using mass spectrometry. The chemical structure of Chlorothiazide 13C,15N2 consists of a benzothiadiazine ring system with a sulfonamide group attached. The molecular formula of the drug is C7H5ClN3O4S2, and its molecular weight is 318.75 g/mol. The drug is available in oral tablets and injectable formulations, with a typical dosage range of 12.5-50 mg/day for adults. Chlorothiazide 13C,15N2 may cause some side effects, including electrolyte imbalances, hypotension (low blood pressure), hyperuricemia (high uric acid levels), and allergic reactions. It should not be used in patients with severe renal impairment or anuria (absence of urine production). The drug may interact with other medications, such as lithium, digoxin, and corticosteroids, and should be used with caution in patients with diabetes or gout.