(E/Z)-4,4'-Dihydroxy-N-desmethyl Tamoxifen-d3
| Product Name | (E/Z)-4,4'-Dihydroxy-N-desmethyl Tamoxifen-d3 |
|---|---|
| Alternate Names | Tamoxifen Stable Isotopes, Stable Isotopes of Tamoxifen |
| CAT No. | CS-T-53203 |
| CAS No. | 1246832-93-8 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Tamoxifen |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=C(C=C3)O |
| Canonical Smiles | CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=C(C=C3)O |
| InchIKey | JYBJJTCUEOUMEV-CANUYGMUSA-N |
| Inchl | InChI=1S/C25H27NO3/c1-3-24(18-4-10-21(27)11-5-18)25(19-6-12-22(28)13-7-19)20-8-14-23(15-9-20)29-17-16-26-2/h4-15,26-28H,3,16-17H2,1-2H3/b25-24-/i2D3 |
| IUPAC | 4-[(Z)-1-(4-hydroxyphenyl)-1-[4-[2-(trideuteriomethylamino)ethoxy]phenyl]but-1-en-2-yl]phenol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
(E/Z)-4,4'-Dihydroxy-N-desmethyl Tamoxifen-d3 is a deuterated form of Tamoxifen, a Selective Estrogen Receptor Modulator (SERM) used in the treatment of breast cancer. This compound is used in laboratory research to study the metabolism and pharmacokinetics of Tamoxifen and its metabolites.
Tamoxifen is converted in the liver by the enzymes CYP2D6 and CYP3A4 into its active metabolites, 4-hydroxytamoxifen (4-OHT) and endoxifen, which bind to the estrogen receptor and inhibit the growth of estrogen-sensitive breast cancer cells. (E/Z)-4,4'-Dihydroxy-N-desmethyl Tamoxifen-d3 can be used to study the metabolism of Tamoxifen and its metabolites by using it as a tracer in mass spectrometry experiments.
The compound has a molecular formula of C26H26D3N2O4 and a molecular weight of 437.55 g/mol. It is available as a white to off-white powder and is stable under normal laboratory conditions. The chemical structure of (E/Z)-4,4'-Dihydroxy-N-desmethyl Tamoxifen-d3 contains deuterium atoms at the 3rd, 4th, and 5th positions of the phenyl ring, which allows for its use as a stable isotope-labelled internal standard in LC-MS/MS analysis.
In conclusion, (E/Z)-4,4'-Dihydroxy-N-desmethyl Tamoxifen-d3 is an important research tool used to study the metabolism and pharmacokinetics of Tamoxifen and its metabolites. Its stable isotopic labeling allows for precise quantification of Tamoxifen and its metabolites in biological samples, which is important for understanding their role in breast cancer treatment and drug resistance.
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Related Compounds
N-Desmethyl-4-hydroxy Tamoxifen-d5 (1:1 E/Z Mixture) | Tamoxifen 13C6 | Tamoxifen-13C6 | N-Desmethyl Tamoxifen-d5 | N-Desmethyl N-Nitroso Tamoxifen-D3 | Tamoxifen-D5 | Tamoxifen-d3 | N-Desmethyl-4-hydroxy Tamoxifen-d5 β-D-Glucuronide (E/Z Mixture) |