2-Hydroxy Atorvastatin-D5 Acetonide tert-Butyl Ester

2-Hydroxy Atorvastatin-D5 Acetonide tert-Butyl Ester is a chemical compound that is used in the pharmaceutical industry as a starting material for the synthesis of Atorvastatin, a well-known cholesterol-lowering medication. This compound is a deuterated derivative of Atorvastatin that is specifically designed for use in pharmacokinetic studies, as it allows researchers to track the movement and metabolism of Atorvastatin in the body more accurately. The chemical formula of 2-Hydroxy Atorvastatin-D5 Acetonide tert-Butyl Ester is C39H47D5NO5, and it has a molecular weight of 639.88 g/mol. It is a white to off-white powder that is soluble in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO). The compound is typically synthesized using a series of chemical reactions, beginning with the reaction of Atorvastatin with tert-butyl acetate and acetic anhydride to form the acetonide derivative. This is followed by the introduction of deuterium atoms at specific positions using deuterated reagents, resulting in the final product of 2-Hydroxy Atorvastatin-D5 Acetonide tert-Butyl Ester. Overall, the compound is an important tool for pharmacological research, as it enables scientists to better understand the mechanisms of action and metabolism of Atorvastatin, and potentially develop more effective treatments for cholesterol-related conditions.