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2-Hydroxy Atorvastatin Lactone D5

Product Information

Product 2-Hydroxy Atorvastatin Lactone D5
CAT No. CS-T-55832
CAS No. 265989-50-2
Status Available for Dispatch by 24-Sep-2023
Category Stable Isotopes
Mol. Wt. 561.65 mol/g
Mol. For. C₃₃H₂₈D₅FN₂O₅
Hazardous Hazard

Product Description

2-Hydroxy Atorvastatin Lactone D5 is a synthetic compound that is used in research studies to investigate the metabolism and pharmacokinetics of atorvastatin, a medication used to lower cholesterol levels and prevent heart disease. Atorvastatin is a member of the statin class of drugs, which work by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a key enzyme in the cholesterol biosynthesis pathway. Atorvastatin lactone is an active metabolite of atorvastatin, formed by the hydrolysis of the lactone ring in the parent compound. 2-Hydroxy Atorvastatin Lactone D5 is labeled with deuterium at five positions, which allows it to be used as a tracer in metabolic studies. It is metabolized in a similar manner to atorvastatin lactone, and its presence in biological samples can be quantified using mass spectrometry. This information can be used to determine the pharmacokinetic properties of atorvastatin and its metabolites, such as their absorption, distribution, metabolism, and excretion. The chemical formula of 2-Hydroxy Atorvastatin Lactone D5 is C33H30D5F2O5, and its molecular weight is 569.64 g/mol. It is a white to off-white powder that is soluble in organic solvents such as methanol and acetonitrile. It should be stored at -20°C in a dry, sealed container, away from light and moisture. As with all research chemicals, proper handling and disposal procedures should be followed to minimize the risk of exposure and harm.

Additional Information

Packing Product will be supplied in Vials, in certain conditions we also use 'Septa Vials'
Controlled No
Parent API Atorvastatin
Therapeutic Anti-Diabetic
Canonical Smiles CC(C)C1=C(C(=C(N1CCC2CC(CC(=O)O2)O)C3=CC=C(C=C3)F)C4=CC=CC=C4)C(=O)NC5=CC=CC=C5O
Inchl InChI=1S/C33H33FN2O5/c1-20(2)31-30(33(40)35-26-10-6-7-11-27(26)38)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-25-18-24(37)19-28(39)41-25/h3-15,20,24-25,37-38H,16-19H2,1-2H3,(H,35,40)/t24-,25-/m1/s1/i3D,4D,5D,8D,9D
IUPAC 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-(2,3,4,5,6-pentadeuteriophenyl)-2-propan-2-ylpyrrole-3-carboxamide
Hazardous No

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Safety & Handling Information

General Information Use proper personal protective equipment
Handling Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Engineering Control Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Clothing Wear appropriate protective clothing to minimize contact with skin.
Skin Wear appropriate protective gloves and clothing to prevent skin exposure.
Eyes Wear safety glasses and chemical goggles if splashing is possible.
Inhalation Remove from exposure and move to fresh air immediately.

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Sample Label

logo 2-Hydroxy Atorvastat... www.clearsynth.com 
 CAT : CS-T-55832 BATCH : CSC-WWW0757

 MF: C₃₃H₂₈D₅FN₂O₅
 CAS: 265989-50-2
 Date of Anaysis: 19-Aug-2023
 Retest Date: 19-Jun-2026
MW: 561.65

Store at refrigerator (2-8C)
Qty: 60 MG 
 Only for R & D and Analytical purpose, Not for Human Consumption.

Sample Packaging

Sample Packaging

Sample Vials

Sample Vials
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