5-Hydroxy Omeprazole-D3

5-Hydroxy Omeprazole-D3 is a deuterated derivative of the proton-pump inhibitor omeprazole, which is used to treat gastroesophageal reflux disease (GERD) and other acid-related disorders. It is labeled with three deuterium atoms in the 5-hydroxy group, which enhances the stability of the molecule and improves the sensitivity and accuracy of analytical methods. The chemical structure of 5-Hydroxy Omeprazole-D3 contains a substituted benzimidazole ring and a pyridine ring, which interact with the H+/K+-ATPase enzyme in the parietal cells of the stomach to inhibit the secretion of gastric acid. The deuterium labeling does not affect the mechanism of action of omeprazole, but it allows for the quantification of the drug and its metabolites in biological samples by mass spectrometry. 5-Hydroxy Omeprazole-D3 is typically used as a reference standard or internal standard in pharmacokinetic studies, bioanalytical assays, and drug-drug interaction studies. It can also be used to investigate the metabolism, distribution, and excretion of omeprazole in vivo and in vitro. The deuterium labeling increases the selectivity and accuracy of these studies, as it minimizes interference from endogenous compounds and other drugs that may have similar chemical properties. Overall, 5-Hydroxy Omeprazole-D3 is a useful tool for researchers and clinicians who are interested in understanding the pharmacology and pharmacokinetics of omeprazole and its derivatives, and for developing new therapies for acid-related disorders.