(2R,3S,4S,5S) -5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone

(2R,3S,4S,5S)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone, commonly known as HTMT, is a chemical compound used in organic chemistry, particularly in the field of medicinal chemistry. It is a white to off-white crystalline powder that is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and acetonitrile. HTMT is a chiral compound, meaning it exists in two mirror-image forms. The specific stereochemistry of (2R,3S,4S,5S)-5-hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone has been found to be important for its activity in certain biological assays. HTMT has been shown to have potential as an anti-tumor agent, as it has been found to inhibit the growth of certain cancer cells. Additionally, HTMT has been investigated for its potential as a neuroprotective agent, as it has been shown to protect neurons from damage caused by oxidative stress. In terms of chemical structure, HTMT contains a cyclohexanone ring and several phenylmethoxy groups. The compound is synthesized using a multi-step process that involves the use of reagents such as sodium hydride and dimethyl sulfate. Overall, (2R,3S,4S,5S)-5-hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone is a promising compound with potential applications in the fields of cancer research and neuroprotection.