5-Hydroxyindole-3-acetic Acid D5

5-Hydroxyindole-3-acetic Acid D4 (5-HIAA D4) is a stable isotope-labeled version of 5-hydroxyindole-3-acetic acid. It is a metabolite of the neurotransmitter serotonin, and is primarily excreted in urine. 5-HIAA D4 is commonly used as an internal standard in clinical research and medical testing of neuroendocrine tumors, particularly in the monitoring of carcinoid tumors. The chemical structure of 5-HIAA D4 is very similar to that of the non-labeled version, with the only difference being the presence of four deuterium atoms in the molecule. This stable isotope labeling allows for accurate and precise quantification of 5-HIAA in biological samples, as it eliminates the potential for interference from other compounds. In terms of usage, 5-HIAA D4 is typically added to biological samples prior to analysis using mass spectrometry. This allows for the accurate measurement of the concentration of 5-HIAA in the sample, and can be used to monitor disease progression or treatment efficacy. It is also used in laboratory research to investigate the mechanisms of serotonin metabolism and signaling in the brain. Overall, 5-HIAA D4 is a valuable tool in clinical and laboratory settings for accurately measuring 5-hydroxyindole-3-acetic acid levels and studying serotonin metabolism. Its stable isotope labeling allows for precise quantification and eliminates potential interference, making it a reliable internal standard for use in medical testing and research.