Ivacaftor D18 (D17 Major)
| Product Name | Ivacaftor D18 (D17 Major) |
|---|---|
| Alternate Names | Ivacaftor Stable Isotopes, Stable Isotopes of Ivacaftor |
| CAT No. | CS-T-56697 |
| CAS No. | 1413431-05-6 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 410.60 g/mol |
| Mol. For. | C₂₄H₁₀D₁₈N₂O₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Ivacaftor |
| Purity | 95% |
| Smileys | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C |
| Canonical Smiles | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C |
| InchIKey | PURKAOJPTOLRMP-UHFFFAOYSA-N |
| Inchl | InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) |
| IUPAC | N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Ivacaftor D18 is a drug used for the treatment of cystic fibrosis (CF) in patients with a specific genetic mutation. CF is a genetic disorder that affects the lungs, digestive system, and other organs, and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor D18 is designed to target a specific mutation in the CFTR gene, known as the G551D mutation, which affects approximately 4% of patients with CF.
The mechanism of action of Ivacaftor D18 is to increase the activity of the CFTR protein in the cells, which helps to improve the flow of salt and water across the cell membrane. This results in improved lung function and reduced respiratory symptoms in patients with CF. Ivacaftor D18 is administered orally in the form of tablets, usually twice a day.
Chemically, Ivacaftor D18 is a small molecule drug that belongs to the class of drugs known as CFTR potentiators. It has a molecular weight of 392.5 g/mol and a chemical formula of C24H28N2O3. Ivacaftor D18 is metabolized in the liver and excreted in the feces, with a half-life of approximately 12 hours.
Ivacaftor D18 has been shown to be effective in clinical trials in improving lung function and reducing respiratory symptoms in patients with CF. It is generally well-tolerated, with common side effects including headache, dizziness, and nausea. However, as with any medication, it may not be suitable for all patients. It is important to consult with a healthcare provider before starting any new medication.
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Related Compounds
Ivacaftor-D19 | Ivacaftor 13C6 | Ivacaftor D6 | Ivacaftor (4-tertbutyl-d9) |