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Methylmalonic acid D3 is an isotopically labeled form of methylmalonic acid that is used in various scientific applications. It is commonly used as an analytical standard in the field of clinical chemistry to measure the level of methylmalonic acid in blood and urine samples. This acid is a dicarboxylic acid that is formed during the metabolism of certain amino acids and fatty acids. It is a key intermediate in the production of succinyl-CoA, which is an essential molecule in the tricarboxylic acid cycle.
The D3 isotopic label in methylmalonic acid is used to facilitate accurate quantification of this molecule in biological samples. This label essentially replaces three hydrogen atoms in the molecule with deuterium atoms, which allows for easy detection and measurement of the molecule using techniques such as gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry.
Methylmalonic acid D3 is also used in research related to vitamin B12 deficiency, as elevated levels of this acid in blood and urine samples are often indicative of this deficiency. Additionally, this acid has been studied for its potential use as a biomarker for various diseases, including Alzheimer’s disease and diabetes.
Overall, methylmalonic acid D3 is a valuable analytical tool in the field of clinical chemistry and biomedical research, helping to improve our understanding of various diseases and metabolic processes.
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