5-[4-[2-((Methyl-d3)pyridin-2-ylamino)ethoxy]benzylidene]thiazolidine-2,4-dione

5-[4-[2-((Methyl-d3)pyridin-2-ylamino)ethoxy]benzylidene]thiazolidine-2,4-dione is a chemical compound that belongs to the family of thiazolidinediones, which are used as antidiabetic drugs. This particular compound is a deuterated analog of the drug pioglitazone, which is used to improve insulin sensitivity and regulate blood sugar levels in patients with type 2 diabetes. The compound works by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor that plays a crucial role in glucose and lipid metabolism. PPAR-γ activation leads to an increased uptake of glucose by the cells and a decrease in insulin resistance, which in turn lowers blood sugar levels. The deuterated form of the compound, 5-[4-[2-((Methyl-d3)pyridin-2-ylamino)ethoxy]benzylidene]thiazolidine-2,4-dione, is used in research studies to track the metabolism and pharmacokinetics of pioglitazone in vivo. The deuterium atoms in the compound act as isotopic labels, allowing for the identification and quantification of pioglitazone and its metabolites in biological samples using mass spectrometry. In conclusion, 5-[4-[2-((Methyl-d3)pyridin-2-ylamino)ethoxy]benzylidene]thiazolidine-2,4-dione is a useful chemical compound that has both therapeutic and research applications. Its ability to activate PPAR-γ and regulate glucose metabolism makes it a promising drug candidate for the treatment of type 2 diabetes, while its deuterated form provides a powerful tool for studying the pharmacokinetics and metabolism of pioglitazone in vivo.