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Chemical Name A-887826-d8
CAT No. CS-T-64039
CAS No. 1794753-88-0
Status price
Category Stable Isotopes
Hazardous This is not a Hazardous Compound
COA View Sample COA
Controlled No

Additional Information

Packing Product will be supplied in Vials, in certain conditions we also use 'Septa Vials'
Controlled No
Smileys CCCCOC1=C(C=C(C=C1)C2=CC(=CN=C2)C(=O)NCC3=C(N=CC=C3)N4CCOCC4)Cl
Canonical Smiles CCCCOC1=C(C=C(C=C1)C2=CC(=CN=C2)C(=O)NCC3=C(N=CC=C3)N4CCOCC4)Cl
Inchl InChI=1S/C26H29ClN4O3/c1-2-3-11-34-24-7-6-19(15-23(24)27)21-14-22(17-28-16-21)26(32)30-18-20-5-4-8-29-25(20)31-9-12-33-13-10-31/h4-8,14-17H,2-3,9-13,18H2,1H3,(H,30,32)/i9D2,10D2,12D2,13D2
IUPAC 5-(4-butoxy-3-chlorophenyl)-N-[[2-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)pyridin-3-yl]methyl]pyridine-3-carboxamide
Hazardous No

Usage and description

A-887826-d8 is a chemical compound used in scientific research as a selective and potent antagonist for the GPR40 receptor. This receptor is found in pancreatic islet cells and plays a crucial role in glucose-dependent insulin secretion. The compound is used to investigate the role of GPR40 in insulin secretion and glucose metabolism. Chemically, A-887826-d8 is a derivative of A-887826, a compound that was originally discovered in a screening program for GPR40 antagonists. The "d8" in the name refers to the deuterium atom present in the molecule, which is used to enhance its stability and reduce the potential for metabolic degradation. A-887826-d8 is typically administered to laboratory animals in order to study its effects on insulin secretion and glucose metabolism. It has been shown to reduce glucose-stimulated insulin secretion in mice and to improve glucose tolerance in rats. These findings suggest that GPR40 antagonists such as A-887826-d8 may have therapeutic potential for the treatment of type 2 diabetes. In summary, A-887826-d8 is a chemical compound used in scientific research to investigate the role of the GPR40 receptor in insulin secretion and glucose metabolism. Its chemical structure includes a deuterium atom to enhance stability, and it has shown promising results in animal studies as a potential treatment for type 2 diabetes.

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