2-Amino-6-mercaptopurine-13C2,15N
| Product Name | 2-Amino-6-mercaptopurine-13C2,15N |
|---|---|
| Alternate Names | Mercaptopurine Stable Isotopes, Stable Isotopes of Mercaptopurine |
| CAT No. | CS-T-65950 |
| CAS No. | 1330266-29-9 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | 170.17 g/mol |
| Mol. For. | C₃¹³C₂H₅N₄¹⁵NS |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Mercaptopurine |
| Smileys | NC1=N[13C]2=[13C](C(S)=N1)[15N]=CN2 |
| Canonical Smiles | C1=NC2=C(N1)C(=S)N=C(N2)N |
| InchIKey | WYWHKKSPHMUBEB-QZTPXDJLSA-N |
| Inchl | InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)/i2+1,3+1,7+1 |
| IUPAC | 2-amino-3,7-dihydropurine-6-thione |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
2-Amino-6-mercaptopurine-13C2,15N is a stable isotope-labeled analog of the purine derivative 6-mercaptopurine (6-MP). It is commonly used in biochemical research to study the metabolism and pharmacokinetics of 6-MP, a drug used in the treatment of leukemia, autoimmune disorders and inflammatory bowel disease.
The chemical formula of 2-Amino-6-mercaptopurine-13C2,15N is C5H3N4S, with the addition of two carbon-13 atoms and one nitrogen-15 atom. The stable isotope-labeled compound is used in tracer studies to determine the pharmacokinetics of 6-MP in vivo. It is also used in studies to elucidate the metabolic pathways of 6-MP in the body.
The compound is typically administered orally as a prodrug, which is then metabolized in the liver to its active form, 6-thioguanine nucleotides (6-TGNs). These metabolites inhibit DNA synthesis and cell proliferation, leading to their use in the treatment of leukemia and autoimmune disorders.
Overall, 2-Amino-6-mercaptopurine-13C2,15N is a valuable tool in biochemical research, allowing for the study of the metabolism and pharmacokinetics of 6-MP. Its stable isotope labeling provides a reliable method for tracer studies, aiding in the understanding of the mechanisms of action of this important drug.
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