(S)-(+)-Camptothecin-d5

(S)-(+)-Camptothecin-d5 is a deuterated form of the naturally occurring anti-cancer drug, (S)-(+)-Camptothecin. This isotopically labeled drug is used in research studies to investigate the metabolism and pharmacokinetics of the parent drug. The chemical formula of (S)-(+)-Camptothecin-d5 is C20H12D5N3O4 and it has a molecular weight of 377.43 g/mol. The drug is a potent inhibitor of topoisomerase I, an enzyme involved in DNA replication and repair. By inhibiting the activity of this enzyme, (S)-(+)-Camptothecin-d5 prevents cancer cells from dividing and proliferating. The drug is typically administered by intravenous injection and has been shown to be effective against a variety of cancers, including lung, ovarian, and colorectal cancers. However, due to its toxicity and narrow therapeutic window, (S)-(+)-Camptothecin-d5 is not currently used as a standard treatment for cancer. In research studies, (S)-(+)-Camptothecin-d5 is used as a tracer to study the pharmacokinetics and metabolism of the parent drug. By labeling the drug with deuterium, researchers can track its movement through the body and determine how it is metabolized and eliminated. This information can be used to optimize dosing regimens and improve the efficacy of (S)-(+)-Camptothecin and other anti-cancer drugs.