(R)-(-)-Camptothecin-d5
| Product Name | (R)-(-)-Camptothecin-d5 |
|---|---|
| Alternate Names | Camptothecin Stable Isotopes, Stable Isotopes of Camptothecin |
| CAT No. | CS-T-68999 |
| CAS No. | 1329793-44-3 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Camptothecin |
| Smileys | O=C1OCC(C(N2CC3=CC4=CC=CC=C4N=C3C2=C5)=O)=C5C1(O)C([2H])([2H])C([2H])([2H])[2H] |
| Canonical Smiles | CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O |
| InchIKey | VSJKWCGYPAHWDS-XNUBIDPZSA-N |
| Inchl | InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m1/s1/i1D3,2D2 |
| IUPAC | (19R)-19-hydroxy-19-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
(R)-(-)-Camptothecin-d5 is a deuterated derivative of the natural plant alkaloid, camptothecin. It is a potent antitumor agent and exhibits significant cytotoxic activity against various cancer cells. This compound is used in cancer research as a tool to study the mechanisms of action of camptothecin and its analogues.
The deuterium-labeled version of camptothecin allows for the determination of the metabolic fate and pharmacokinetic properties of the compound in vivo. The deuterium atoms replace the hydrogen atoms in the molecule, which can affect the compound's stability, solubility, and reactivity. This allows for more accurate quantification of the compound in biological samples and helps to better understand its biological activity.
(R)-(-)-Camptothecin-d5 is a topoisomerase I inhibitor, which means it interferes with the DNA replication process and prevents cancer cells from dividing and proliferating. The compound has shown efficacy against various types of cancer, including lung, breast, and colon cancers, making it a promising candidate for cancer therapy.
In conclusion, (R)-(-)-Camptothecin-d5 is a valuable tool for cancer research and drug development. Its ability to selectively target cancer cells and inhibit their growth makes it a promising candidate for cancer treatment. The deuterated version of the compound allows for more accurate and detailed studies of its pharmacokinetic and metabolic properties, which can aid in the development of more effective cancer therapies.
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