2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol-d5

2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol-d5 is a deuterated analog of the drug GNF-2, which is an allosteric modulator of the guanine nucleotide exchange factor (GEF) activity of the protein ARNO. ARNO is a regulator of the small GTPases ARF6 and ARF1, which are involved in membrane trafficking and cytoskeletal rearrangement. GNF-2 has been shown to inhibit ARNO-mediated activation of ARF6, leading to decreased cell migration and invasion. 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol-d5 can be used in studies of ARNO and ARF6 signaling pathways, as well as drug discovery efforts targeting these proteins. Its deuterium labeling allows for more precise measurement of drug metabolism and pharmacokinetics in vivo. In terms of chemical information, 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol-d5 has a molecular formula of C20H13D5FNO, and a molecular weight of 315.36 g/mol. Its melting point is approximately 137-139°C, and its solubility in water is low. It is typically supplied as a white or off-white powder for use in research applications. Overall, 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol-d5 is a valuable tool for investigating ARNO and ARF6 signaling pathways, as well as developing new drugs to target these proteins. Its deuterium labeling enhances its utility in pharmacokinetic studies, making it a valuable addition to the toolkit of researchers in this field.