(R)-(+)-Felodipine-d5
| Product Name | (R)-(+)-Felodipine-d5 |
|---|---|
| Alternate Names | Felodipine Stable Isotopes, Stable Isotopes of Felodipine |
| CAT No. | CS-T-75443 |
| CAS No. | 1217716-73-8 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Felodipine |
| Smileys | O=C(C([C@H](C(C=CC=C1Cl)=C1Cl)C(C(OC)=O)=C(C)N2)=C2C)OC([2H])([2H])C([2H])([2H])[2H] |
| Canonical Smiles | CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C |
| InchIKey | RZTAMFZIAATZDJ-SAFFEWCNSA-N |
| Inchl | InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3/t15-/m0/s1/i1D3,5D2 |
| IUPAC | 3-O-methyl 5-O-(1,1,2,2,2-pentadeuterioethyl) (4S)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
(R)-(+)-Felodipine-d5 is a deuterated form of the calcium channel blocker Felodipine, used in the treatment of hypertension and angina. It is a chiral compound, with the (R)-enantiomer being the active form in vivo. The deuterated form, (R)-(+)-Felodipine-d5, is used as an internal standard in pharmacokinetic and bioanalytical studies to determine drug concentrations in biological samples.
Felodipine works by blocking the entry of calcium ions into smooth muscles, leading to vasodilation and a decrease in blood pressure. The deuterated form, (R)-(+)-Felodipine-d5, is chemically identical to Felodipine, with the exception of five deuterium atoms replacing five hydrogen atoms. This substitution does not affect the pharmacological properties of the drug, but makes it easier to detect and quantify in biological samples using analytical techniques such as liquid chromatography-mass spectrometry.
The use of (R)-(+)-Felodipine-d5 as an internal standard allows for accurate and precise measurement of Felodipine concentrations in biological samples, which is essential for determining the efficacy and safety of the drug in clinical trials. It is also used in drug metabolism studies to understand the pharmacokinetic properties of Felodipine in the body. The deuterated form is a valuable tool in drug development and research, enabling scientists to better understand the pharmacological and metabolic properties of Felodipine.
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Related Compounds
Felodipine D5 | Dehydrofelodipine 13C4 | rac Felodipine-d8 | Dehydro Felodipine-d3 | O-Desmethyl Felodipine-d5 | Felodipine D3 (Methoxy-d3) |