7-Ethyl-10-(4-[[benzylcarbamoyl]amino]-1-piperidino)carbonyloxycamptothecin-d3

7-Ethyl-10-(4-[[benzylcarbamoyl]amino]-1-piperidino)carbonyloxycamptothecin-d3, also known as SN-38-d3, is a deuterated derivative of the active metabolite of the anticancer agent irinotecan. Irinotecan, also known as CPT-11, is a topoisomerase I inhibitor used in the treatment of various types of cancer, including colorectal, lung, and ovarian cancer. SN-38-d3 is a stable isotope-labeled analog of SN-38, which can be used as an internal standard for quantification of SN-38 in biological samples. SN-38-d3 has the same mechanism of action as SN-38. It inhibits topoisomerase I, an enzyme responsible for DNA replication and repair, leading to DNA damage and ultimately cell death. In addition to its use as an internal standard, SN-38-d3 can also be used in metabolic studies to investigate the metabolism and pharmacokinetics of irinotecan. The chemical formula of SN-38-d3 is C27H23D3N4O7, and its molecular weight is 527.56 g/mol. It is a yellow to orange crystalline powder that is soluble in DMSO, methanol, and ethanol. SN-38-d3 should be stored in a cool, dry place and protected from light. In conclusion, SN-38-d3 is a useful tool in cancer research for quantification and metabolic studies. Its stable isotope-labeled structure allows for accurate measurement of SN-38 levels in biological samples, aiding in the development of effective cancer treatments.