10-Hydroxy Camptothecin-d5

10-Hydroxy Camptothecin-d5 is a deuterated analog of the anti-cancer drug 10-Hydroxy Camptothecin (HCPT). HCPT is a natural alkaloid isolated from the bark and stem of the Chinese tree Camptotheca acuminata, and has been shown to have potent anti-tumor activity. However, its use in clinical settings has been limited by its poor solubility and stability. 10-Hydroxy Camptothecin-d5 is a deuterated version of HCPT, meaning that some of its hydrogen atoms have been replaced with deuterium atoms. This modification increases its stability, solubility, and bioavailability, making it a more effective anti-cancer drug. The chemical formula of 10-Hydroxy Camptothecin-d5 is C20H13D5N2O5, and it has a molecular weight of 369.42 g/mol. It works by inhibiting the activity of topoisomerase I, an enzyme that is necessary for DNA replication and repair. By preventing topoisomerase I from functioning properly, 10-Hydroxy Camptothecin-d5 causes DNA damage and ultimately leads to the death of cancer cells. In terms of usage, 10-Hydroxy Camptothecin-d5 is typically administered intravenously in clinical settings. It is used to treat a variety of cancers, including lung, ovarian, and breast cancer. However, like other chemotherapeutic drugs, it can cause side effects such as nausea, vomiting, and hair loss. Overall, 10-Hydroxy Camptothecin-d5 has shown promise as a more effective and tolerable anti-cancer drug than its non-deuterated counterpart.