3-Hydroxy Anagrelide-13C3
| Chemical Name | 3-Hydroxy Anagrelide-13C3 |
|---|---|
| Alternate Names | Anagrelide Stable Isotopes, Stable Isotopes of Anagrelide |
| CAT No. | CS-T-78466 |
| CAS Registry# | 1219393-12-0 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Anagrelide |
| Smileys | O=[13C]1N[13C]2=NC3=C(C(Cl)=C(Cl)C=C3)CN2[13CH]1O |
| Canonical Smiles | C1C2=C(C=CC(=C2Cl)Cl)N=C3N1C(C(=O)N3)O |
| InchIKey | KAXTUTDKZVOONF-SKMPNTIBSA-N |
| Inchl | InChI=1S/C10H7Cl2N3O2/c11-5-1-2-6-4(7(5)12)3-15-9(17)8(16)14-10(15)13-6/h1-2,9,17H,3H2,(H,13,14,16)/i8+1,9+1,10+1 |
| IUPAC | 6,7-dichloro-3-hydroxy-3,5-dihydro-1H-(2,4,5-13C3)imidazolo[2,1-b]quinazolin-2-one |
| Controlled | No |
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3-Hydroxy Anagrelide-13C3 is a stable isotope-labeled derivative of Anagrelide, which is an orally available medication used in the treatment of essential thrombocythemia (ET), a blood disorder characterized by the overproduction of platelets. The addition of three carbon-13 isotopes to the molecular structure of Anagrelide allows for the use of advanced analytical techniques, such as mass spectrometry, to track its metabolic fate and pharmacokinetics in vivo.
3-Hydroxy Anagrelide-13C3 is primarily used as a research tool for studying the metabolism, pharmacokinetics, and drug-drug interactions of Anagrelide. It can also be used in metabolic labeling studies to identify and quantify protein modifications and metabolic pathways. The use of stable isotopes in drug development and research has become increasingly important in recent years, as it allows for the precise measurement of drug concentrations and metabolites in biological samples.
From a chemical perspective, 3-Hydroxy Anagrelide-13C3 has a molecular formula of C11H6D3N3O3 and a molecular weight of 257.21 g/mol. Its chemical structure consists of a pyrazolo[1,5-a]pyrimidine core with a hydroxyl group and three carbon-13 isotopes located at specific positions. Its solubility and stability properties are similar to those of Anagrelide, although the incorporation of stable isotopes may affect its biological activity and toxicity. Overall, 3-Hydroxy Anagrelide-13C3 represents a valuable tool for drug research and development, with potential applications in both academia and industry.
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Related Compounds
Anagrelide 13C3 | Anagrelide 13C2-15N-D2 |