3-Hydroxyanthranilic Acid-d3

3-Hydroxyanthranilic Acid-d3 is a deuterated form of 3-hydroxyanthranilic acid (3-HAA), which is a metabolite of the amino acid tryptophan. It is often used as a stable isotope internal standard in mass spectrometry-based analytical techniques. This form of 3-HAA contains three deuterium atoms, which replaces three hydrogen atoms in the molecule. This substitution enhances the accuracy and sensitivity of analytical assays by reducing the effects of isotopic interferences. 3-HAA has been implicated in various physiological processes, including the immune response, oxidative stress, and neurodegenerative disorders. It is also involved in the kynurenine pathway, which is a series of enzymatic reactions that metabolize tryptophan. In this pathway, 3-HAA is formed by the oxidation of anthranilic acid by the enzyme kynurenine 3-monooxygenase. The chemical formula of 3-Hydroxyanthranilic Acid-d3 is C7H5D3NO3, and its molecular weight is 173.18 g/mol. It is a white to off-white crystalline powder that is soluble in water, ethanol, and dimethyl sulfoxide. Its melting point is approximately 250°C. The compound is stable under normal conditions, but it should be kept away from sources of heat and light to prevent degradation. Overall, 3-Hydroxyanthranilic Acid-d3 is a valuable analytical tool for studying the metabolism of tryptophan and its role in various physiological processes.