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Rac trans-4-Hydroxy Glyburide-13C,d3, also known as 4-Hydroxy glyburide, is a stable isotope-labeled analog of the antidiabetic drug, glyburide. This compound is a potent sulfonylurea drug that is used to treat type 2 diabetes. It works by stimulating the secretion of insulin from the pancreas and increasing insulin sensitivity in peripheral tissues. This leads to a reduction in blood glucose levels and better glucose control in diabetic patients.
Rac trans-4-Hydroxy Glyburide-13C,d3 is used in various research studies as a tracer molecule to investigate the pharmacokinetics and pharmacodynamics of glyburide in vivo. Its isotopic labeling allows for the accurate measurement of drug concentration, metabolism, and excretion in biological samples using mass spectrometry. Additionally, it can be used to study drug-drug interactions and investigate the mechanisms of drug resistance and toxicity.
Chemically, Rac trans-4-Hydroxy Glyburide-13C,d3 is a white to off-white powder that is stable under normal laboratory conditions. It has a molecular weight of 389.48 g/mol and a chemical formula of C16H16N3O4S. This compound is soluble in dimethyl sulfoxide, ethanol, and methanol. However, it is insoluble in water and most aqueous solutions.
In conclusion, Rac trans-4-Hydroxy Glyburide-13C,d3 is a useful compound for studying the pharmacology and pharmacokinetics of glyburide. Its isotopic labeling allows for accurate measurement of drug concentration and metabolism in biological samples. This compound has potential applications in drug discovery and development, as well as in clinical research.
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