6-Methylthioguanine-d3

6-Methylthioguanine-d3 is a deuterated version of 6-Methylthioguanine, which is a purine nucleobase analogue. It is used in research as an internal standard for the quantification of 6-Methylthioguanine in biological samples using analytical techniques such as liquid chromatography-mass spectrometry (LC-MS). The deuterium substitution in 6-Methylthioguanine-d3 provides a distinct isotopic pattern that enables accurate quantification of the compound in complex biological matrices. This internal standard is often used in pharmacokinetic studies and drug metabolism research to understand the absorption, distribution, metabolism, and excretion of 6-Methylthioguanine and related compounds. Chemically, 6-Methylthioguanine-d3 is a purine nucleobase analogue with a molecular formula of C6H4D3N5OS. It has a molecular weight of 199.22 g/mol and a melting point of 305-306°C. The compound is stable under normal laboratory conditions and can be stored at room temperature for extended periods. In conclusion, 6-Methylthioguanine-d3 is a useful internal standard for the quantification of 6-Methylthioguanine in biological samples. Its unique isotopic pattern provides accurate quantification and enables researchers to gain insights into drug metabolism and pharmacokinetic studies.