6-Methylbenz[a]anthracene-d14

6-Methylbenz[a]anthracene-d14, also known as 6-MeB[a]A-d14, is a deuterated analogue of 6-methylbenz[a]anthracene (6-MeB[a]A), a polycyclic aromatic hydrocarbon (PAH) commonly found in crude oil and coal tar. 6-MeB[a]A-d14 is a valuable tool in analytical chemistry, environmental toxicology, and cancer research. Its deuterated isotopic label allows for precise measurements of its fate and transport in biological systems, as well as identification and quantification in complex mixtures. In vitro and in vivo studies have shown that 6-MeB[a]A-d14 exhibits similar mutagenic and carcinogenic properties as its unlabeled counterpart. It is metabolized in the liver by cytochrome P450 enzymes to form highly reactive intermediates that can bind to DNA and induce mutations. Exposure to PAHs, including 6-MeB[a]A-d14, has been linked to an increased risk of cancer, respiratory diseases, and developmental abnormalities. Therefore, the use and handling of 6-MeB[a]A-d14 should be done with caution and appropriate safety measures to minimize exposure. Overall, 6-MeB[a]A-d14 is a useful chemical tool for understanding the behavior and effects of PAHs in biological systems and the environment. Its precise isotopic labeling provides a unique advantage in research, allowing for sensitive and specific detection and measurement.