N-Methylsulfonyl Dofetilide

N-Methylsulfonyl Dofetilide is a chemical compound that is used in the treatment of various cardiac arrhythmias such as atrial fibrillation, atrial flutter, and ventricular tachycardia. It belongs to a class of drugs called class III anti-arrhythmic agents, which work by blocking the potassium channels in the heart, thus prolonging the cardiac action potential and preventing abnormal heart rhythms. The chemical formula of N-Methylsulfonyl Dofetilide is C19H32N3O5S2, and its molecular weight is 464.62 g/mol. It is a white to off-white powder that is soluble in water and has a pKa of 9.2. N-Methylsulfonyl Dofetilide is typically administered orally or intravenously, and its dosage is dependent on the patient's medical condition, age, and weight. Its half-life in the body is approximately 7-9 hours, and it is metabolized primarily by the liver. Like all medications, N-Methylsulfonyl Dofetilide may have some side effects, such as headaches, dizziness, nausea, and vomiting. It should not be taken by individuals with a history of heart failure, low potassium levels, or other heart rhythm disorders. In conclusion, N-Methylsulfonyl Dofetilide is an effective medication used in the treatment of cardiac arrhythmias. It is important to follow the dosage instructions provided by a healthcare professional and to be aware of any potential side effects.