3-O-Methyl Carbidopa-d5

3-O-Methyl Carbidopa-d5 is a deuterium-labeled version of the drug Carbidopa, a medication commonly used to treat Parkinson's disease. The addition of deuterium to the molecule provides a useful tool for researchers in understanding the metabolism and pharmacokinetics of the drug. Carbidopa works by inhibiting the activity of an enzyme called aromatic L-amino acid decarboxylase (AADC) in the brain, which prevents the breakdown of levodopa, another medication used to treat Parkinson's disease. By inhibiting AADC, Carbidopa allows more levodopa to reach the brain, where it can be converted into the neurotransmitter dopamine, which is depleted in Parkinson's disease. 3-O-Methyl Carbidopa-d5 can be used in studies to determine the metabolic fate of Carbidopa within the body. By monitoring the levels of the labeled molecule in blood or urine samples, researchers can gain insight into the drug's pharmacokinetics, including its absorption, distribution, metabolism, and excretion. Chemically, 3-O-Methyl Carbidopa-d5 is a stable, colorless solid that is soluble in water and other polar solvents. It has a molecular weight of 248.3 g/mol and a molecular formula of C10H11D5N2O4. The deuterium atoms are located at the 3-O-methyl position on the molecule, providing a unique identifier for the labeled compound. Overall, 3-O-Methyl Carbidopa-d5 is a valuable tool for researchers in the field of Parkinson's disease and drug metabolism.