1-Methyl-L-histidine-d5

1-Methyl-L-histidine-d5 is a deuterated version of 1-Methyl-L-histidine, an amino acid that is found in high concentrations in skeletal muscles. This amino acid is commonly used as a biomarker for muscle protein turnover and has been studied extensively in relation to exercise and dietary protein intake. The deuterated version of this amino acid, 1-Methyl-L-histidine-d5, is often used in metabolic studies as a tracer to measure protein turnover rates. In terms of chemical information, 1-Methyl-L-histidine-d5 has a molecular formula of C7H10D5N3O2 and a molecular weight of 176.24 g/mol. It is a stable isotope-labeled compound, meaning that it has been modified to contain deuterium atoms instead of the more common hydrogen atoms. This modification allows for accurate and precise measurements in metabolic studies. When used as a tracer, 1-Methyl-L-histidine-d5 is typically administered orally or intravenously, and its incorporation into newly synthesized protein can be measured using mass spectrometry. This information can be used to calculate protein turnover rates, which are important for understanding muscle metabolism and the effects of diet and exercise on muscle protein synthesis and breakdown. In summary, 1-Methyl-L-histidine-d5 is a useful tool for metabolic studies that involve measuring muscle protein turnover rates. Its stable isotope labeling allows for accurate and precise measurements, and its use as a biomarker for muscle protein turnover has important implications for understanding muscle metabolism and optimizing nutrition and exercise regimens for athletes and individuals with muscle-related health conditions.