6-Mercaptopurine-d2

6-Mercaptopurine-d2 is a deuterated analog of 6-mercaptopurine, which is a purine analog used as an antineoplastic agent. The deuterium incorporation in 6-Mercaptopurine-d2 provides unique benefits in scientific research and clinical applications. 6-Mercaptopurine-d2 is primarily used as a reference standard in mass spectrometry-based studies to determine the metabolic pathways and pharmacokinetics of 6-mercaptopurine. It is also commonly used as an internal standard in clinical research to quantify 6-mercaptopurine in patient samples. Chemically, 6-Mercaptopurine-d2 is a purine analog that inhibits purine synthesis in cells, leading to cell death. It is a prodrug that is metabolized into active metabolites, such as 6-thioguanine nucleotides, which interfere with DNA replication and repair. Thus, it is an effective chemotherapeutic agent against various types of cancer, including acute lymphoblastic leukemia, Crohn’s disease, and ulcerative colitis. However, the use of 6-Mercaptopurine-d2 comes with certain precautions. It is known to cause bone marrow suppression, liver toxicity, and gastrointestinal side effects. Therefore, it should be used with caution and under the supervision of a healthcare professional. In conclusion, 6-Mercaptopurine-d2 is a valuable tool in scientific research and clinical applications. Its deuterium incorporation enhances the accuracy and sensitivity of analytical methods, and its chemical properties make it an effective antineoplastic agent.