4-Nitrobenzoyl-d4 Chloride

4-Nitrobenzoyl-d4 Chloride is a deuterium-labeled derivative of 4-nitrobenzoyl chloride, an organic compound with the chemical formula C7H3D4ClNO3. It is commonly used in chemical synthesis as a reagent for the preparation of various compounds including amino acids, peptides, and esters. As a benzoyl chloride derivative, 4-Nitrobenzoyl-d4 Chloride is a strong electrophile, meaning it is highly reactive towards nucleophiles such as amines and alcohols. This reactivity is attributed to the presence of the nitro group (-NO2) which serves as a powerful electron-withdrawing group that enhances the electrophilicity of the molecule. The deuterium-labeled version of the compound is useful in studies involving isotopic labeling, which is a technique used to trace the fate of specific atoms or functional groups in a chemical reaction or biological process. In addition to its synthetic applications, 4-Nitrobenzoyl-d4 Chloride is also used in biochemical research as a fluorescent labeling reagent for the detection and quantification of proteins and peptides. It is commonly used in mass spectrometry-based proteomics, where it is used to label the N-terminus of peptides for identification and quantification. Overall, 4-Nitrobenzoyl-d4 Chloride is a versatile reagent that finds use in a wide range of chemical and biological applications. Its unique properties make it an essential tool for researchers in various fields including organic synthesis, biochemistry, and proteomics.