Nor Verapamil-d6 Hydrochloride
| Product Name | Nor Verapamil-d6 Hydrochloride |
|---|---|
| Alternate Names | Verapamil Stable Isotopes, Stable Isotopes of Verapamil |
| CAT No. | CS-T-83021 |
| CAS No. | 1329651-21-9 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 483.07 g/mol |
| Mol. For. | C₂₆H₃₁D₆ClN₂O₄ |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Verapamil |
| Smileys | COC(C=C1)=C(OC)C=C1CCNCCCC(C#N)(C2=CC(OC)=C(OC)C=C2)C(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl |
| Canonical Smiles | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl |
| InchIKey | DOQPXTMNIUCOSY-TXHXQZCNSA-N |
| Inchl | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/i1D3,2D3; |
| IUPAC | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)pentanenitrile;hydrochloride |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Nor Verapamil-d6 Hydrochloride is a deuterated derivative of Nor Verapamil, which is a calcium channel blocker medication used in the treatment of hypertension, angina, and certain arrhythmias. The deuterated form of Nor Verapamil is used for drug metabolism studies, as it allows for differentiation between the parent drug and its metabolites in biological samples.
Chemically, Nor Verapamil-d6 Hydrochloride is a white crystalline powder with a molecular weight of 427.97 g/mol. Its chemical formula is C27H30D6ClN2O4, and it has a melting point of 135-140°C.
The mechanism of action of Nor Verapamil is based on its ability to block the calcium channels in the heart and blood vessels, which leads to a reduction in the influx of calcium ions. This, in turn, leads to a decrease in the contractile force of the heart and dilation of blood vessels, resulting in lower blood pressure and reduced oxygen demand by the heart.
The deuterated form of Nor Verapamil, Nor Verapamil-d6 Hydrochloride, is used in metabolic studies to differentiate between the parent drug and its metabolites in biological samples. This is achieved by using mass spectrometry to detect the presence of deuterium-labeled metabolites, which can be distinguished from the unlabeled parent drug.
In conclusion, Nor Verapamil-d6 Hydrochloride is a deuterated derivative of Nor Verapamil used in drug metabolism studies to differentiate between the parent drug and its metabolites in biological samples. Its mechanism of action is based on its ability to block calcium channels, leading to reduced blood pressure and oxygen demand.
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Related Compounds
Verapamil D3 | Verapamil-d6 Hydrochloride | Verapamil D7 Hydrochloride | Verapamil D7 | R-Verapamil-D7 HCL | N-Desmethyl Verapamil D7 Hydrochloride | D 517-d7 Hydrochloride (Verapamil Impurity) | Norverapamil-d7 | S-Verapamil-D7 HCL |