(S)-Naproxen-d6 Methyl Ester

(S)-Naproxen-d6 Methyl Ester is a deuterated derivative of the non-steroidal anti-inflammatory drug, naproxen. It is used as an internal standard in pharmacokinetic studies and in the development of analytical methods for the quantification of naproxen in biological samples. The use of deuterated internal standards in drug analysis improves the accuracy and precision of the results obtained, as it reduces the interference from endogenous compounds or other exogenous compounds that may be present in the sample. Chemically, (S)-Naproxen-d6 Methyl Ester is a deuterated form of (S)-Naproxen Methyl Ester, which is synthesized from (S)-Naproxen and methanol. The deuterated form is obtained by using deuterated methanol in the synthesis process. It is a white to off-white powder that is sparingly soluble in water, but soluble in organic solvents such as methanol, ethanol, and chloroform. The molecular formula of (S)-Naproxen-d6 Methyl Ester is C15H11D6O3, and its molecular weight is 263.34 g/mol. It has a melting point of 82-85°C and a purity of ≥ 98% by HPLC. The compound is stable under normal storage conditions and does not require any special handling or storage precautions. In conclusion, (S)-Naproxen-d6 Methyl Ester is an important analytical tool in the field of pharmacokinetics and drug analysis. Its use as an internal standard improves the accuracy and precision of analytical results and helps in the development of more sensitive and specific analytical methods for drug quantification in biological samples.