15(S)-15-methyl Prostaglandin D2

15(S)-15-methyl Prostaglandin D2, also known as 15(S)-15-methyl PGD2, is a synthetic derivative of prostaglandin D2 (PGD2). It is commonly used in medical research as an agonist for the DP1 and DP2 receptors, which are involved in the regulation of inflammation, immune responses, and smooth muscle contraction. When used as an agonist for the DP1 receptor, 15(S)-15-methyl PGD2 can promote vasodilation, bronchodilation, and inhibition of platelet aggregation. On the other hand, activating the DP2 receptor can lead to the recruitment and activation of immune cells, such as eosinophils and Th2 cells, which are important in allergic responses and asthma. In addition to its research applications, 15(S)-15-methyl PGD2 has also been investigated as a therapeutic agent for various conditions, such as asthma, allergic rhinitis, and alopecia. However, its potential clinical use is limited by its short half-life and potential side effects, such as headache, flushing, and gastrointestinal disturbances. Chemically, 15(S)-15-methyl PGD2 is a lipophilic molecule that belongs to the prostaglandin family. It is structurally similar to endogenous PGD2, with a methyl group attached to the 15th carbon position. This modification enhances its stability and selectivity for the DP receptors.