(R)-(+)-Verapamil-d6 Hydrochloride

(R)-(+)-Verapamil-d6 Hydrochloride is a deuterated form of the calcium channel blocker verapamil, which is used to treat hypertension, angina pectoris, and cardiac arrhythmias. Verapamil works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, which decreases contractility and dilates the blood vessels. This leads to a reduction in blood pressure and improved blood flow to the heart. The deuterated form, (R)-(+)-Verapamil-d6 Hydrochloride, is used in research and drug development for pharmacokinetic and metabolic studies. The deuterium atoms in the molecule slow down the rate of metabolism and elimination, allowing for more accurate measurements of pharmacokinetic parameters. This information is essential for determining optimal dosing regimens and potential drug interactions. Chemically, (R)-(+)-Verapamil-d6 Hydrochloride is a hydrochloride salt of the (R)-enantiomer of verapamil, which is a white crystalline powder. It has a molecular formula of C27H36D6ClN3O4 and a molecular weight of 526.2 g/mol. The compound is soluble in water and ethanol, and has a melting point of 143-146°C. In conclusion, (R)-(+)-Verapamil-d6 Hydrochloride is a useful tool for research and drug development, allowing for more accurate measurements and understanding of its pharmacokinetics and metabolism.