5-[[4-(2-Cyclohexylethoxy)-3-methoxyphenyl]methylene]-2,4-thiazolidinedione-d4

5-[[4-(2-Cyclohexylethoxy)-3-methoxyphenyl]methylene]-2,4-thiazolidinedione-d4 is a deuterium-labeled version of a chemical compound that belongs to the class of thiazolidinediones. It is an effective antidiabetic drug that is primarily used to treat type 2 diabetes mellitus. The compound is also known as pioglitazone-d4, with deuterium atoms replacing four hydrogen atoms in the molecule. Pioglitazone-d4 works by increasing insulin sensitivity in the body, which helps to lower blood sugar levels. This is achieved by activating peroxisome proliferator-activated receptor gamma (PPAR-γ) present in fat cells, liver and muscles. It also reduces insulin resistance by reducing the amount of glucose produced by the liver. This results in improved glycemic control and reduced risk of complications associated with diabetes, such as cardiovascular disease, kidney damage, and blindness. The chemical formula of 5-[[4-(2-Cyclohexylethoxy)-3-methoxyphenyl]methylene]-2,4-thiazolidinedione-d4 is C19H17D4N2O3S, and its molecular weight is 345.50 g/mol. The compound is a pale yellow crystalline powder that is sparingly soluble in water but soluble in methanol and ethanol. In conclusion, 5-[[4-(2-Cyclohexylethoxy)-3-methoxyphenyl]methylene]-2,4-thiazolidinedione-d4 is an important antidiabetic drug that is used to treat type 2 diabetes mellitus. Its chemical properties and mechanism of action make it an effective tool in managing glycemic control and reducing the risk of complications associated with diabetes.