NG,NG’-Dimethyl-L-arginine-d6

NG,NG’-Dimethyl-L-arginine-d6 is a deuterated form of the naturally occurring molecule NG,NG’-Dimethyl-L-arginine (asymmetric dimethylarginine or ADMA) which is a derivative of the amino acid arginine. ADMA is a competitive inhibitor of nitric oxide synthase (NOS), an enzyme that synthesizes nitric oxide (NO) from arginine. Nitric oxide plays a vital role in the cardiovascular system by regulating blood pressure, vascular tone, and platelet aggregation. Therefore, ADMA levels have been associated with various cardiovascular diseases such as hypertension, atherosclerosis, and heart failure. NG,NG’-Dimethyl-L-arginine-d6 is a useful tool for researchers studying the metabolism and biological effects of ADMA. The deuterium atoms, which replace the hydrogen atoms in the molecule, can be used for isotope tracing experiments. Additionally, the chemical properties of NG,NG’-Dimethyl-L-arginine-d6 are identical to those of ADMA, making it an ideal internal standard for mass spectrometry-based quantification of ADMA levels in biological samples. In conclusion, NG,NG’-Dimethyl-L-arginine-d6 is a valuable reagent for researchers investigating the role of ADMA in cardiovascular diseases. Its chemical properties and isotopic labeling make it a powerful tool for isotope tracing experiments and mass spectrometry-based quantification of ADMA levels.