Mycophenolate Mofetil Related Compound B

Mycophenolate Mofetil Related Compound B, also known as MPB, is a structural analog of the immunosuppressive drug Mycophenolate Mofetil (MMF). It is used as a reference standard in the quality control of MMF formulations. MPB is synthesized from guanine, an intermediate in the de novo synthesis of purine nucleotides, and is structurally similar to MMF’s active metabolite, mycophenolic acid (MPA). MPB has a molecular formula of C12H14N4O5 and a molecular weight of 302.27 g/mol. It is a white to off-white powder that is soluble in water, methanol, and ethanol. MPB is stable under normal storage conditions and has a shelf life of three years. Chemically, MPB is classified as a purine analog and functions as a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH). This enzyme is critical for the de novo synthesis of guanine nucleotides that are required for DNA and RNA replication in lymphocytes. By inhibiting IMPDH, MPB suppresses the proliferation of T and B lymphocytes, which are the primary mediators of the immune response. This makes MPB an effective immunosuppressant agent that is used to prevent organ transplant rejection and to treat autoimmune diseases such as lupus, rheumatoid arthritis, and multiple sclerosis. In summary, MPB is a valuable reference standard for the quality control of MMF formulations, and its chemical properties make it an effective immunosuppressive agent with broad therapeutic applications.