Sonidegib-d4 (morphonyl D4)
| Product Name | Sonidegib-d4 (morphonyl D4) |
|---|---|
| Alternate Names | Sonidegib Stable Isotopes, Stable Isotopes of Sonidegib |
| CAT No. | CS-T-93301 |
| CAS No. | 956697-53-3 (Unlabeled) |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 489.52 g/mol |
| Mol. For. | C₂₆H₂₂D₄F₃N₃O₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Sonidegib |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | CC1=C(C=CC=C1C(NC2=CN=C(C=C2)N3C([2H])([2H])[C@@H](O[C@H](C)C3([2H])[2H])C)=O)C4=CC=C(C=C4)OC(F)(F)F |
| Canonical Smiles | CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F |
| InchIKey | VZZJRYRQSPEMTK-CALCHBBNSA-N |
| Inchl | InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+ |
| IUPAC | N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Sonidegib-d4, also known as Morphonyl D4, is a deuterated form of Sonidegib, a Hedgehog pathway inhibitor used in the treatment of basal cell carcinoma. The deuterated form is used in research studies to measure the pharmacokinetic and pharmacodynamic properties of Sonidegib in biological samples.
Sonidegib-d4 is a small molecule that selectively inhibits the Hedgehog signaling pathway by binding to Smoothened (SMO) protein, a transmembrane protein that plays a crucial role in the Hedgehog pathway. This binding leads to the inhibition of downstream transcription factors and the suppression of cell proliferation. The deuterated form of Sonidegib helps researchers to monitor the drug's metabolism, distribution, and elimination in biological samples, as well as its binding affinity to SMO protein.
The usage of Sonidegib-d4 is mainly in preclinical drug development studies, pharmacokinetic studies, and metabolic stability assays. It is used to determine the drug's half-life, clearance rate, and potential drug-drug interactions. The use of Sonidegib-d4 in these studies can provide valuable insights into the drug's safety and efficacy, as well as aid in the development of new therapeutic agents.
In summary, Sonidegib-d4 is a useful research tool for investigating the pharmacokinetic and pharmacodynamic properties of Sonidegib, a Hedgehog pathway inhibitor used in the treatment of basal cell carcinoma. Its usage in preclinical drug development studies and metabolic stability assays can provide critical information for the development of new therapeutic agents for various diseases.
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