(R)-Propranolol-d7 β-D-Glucuronide Sodium Salt

(R)-Propranolol-d7 β-D-Glucuronide Sodium Salt is a stable, deuterated analogue of the β-blocker propranolol. It is a drug metabolite that is formed in the liver through the glucuronidation of propranolol, a medication used to treat hypertension, angina, and other cardiovascular disorders. The glucuronidation process is an important detoxification mechanism in the liver that converts lipophilic compounds like propranolol into more water-soluble forms that can be excreted from the body. The deuterated form of (R)-Propranolol-d7 β-D-Glucuronide Sodium Salt is used in research laboratories as a stable isotope-labeled internal standard in LC-MS/MS assays for the quantification of propranolol and its metabolites in biological samples. The use of deuterated internal standards allows for more accurate and precise measurements, as the isotopic labeling compensates for matrix effects and other potential sources of variability in the analytical method. As the name suggests, (R)-Propranolol-d7 β-D-Glucuronide Sodium Salt is a sodium salt of the glucuronide conjugate, which enhances its solubility in aqueous solutions. The chemical formula of the compound is C16H16D7NNaO9, with a molecular weight of 425.33 g/mol. Its purity and identity can be confirmed using analytical techniques such as NMR spectroscopy, mass spectrometry, and elemental analysis.