(S)-Pregabalin-13C3

(S)-Pregabalin-13C3 is a chemical compound that is used in the treatment of neuropathic pain, epilepsy, and anxiety disorders. It is a chiral molecule, meaning that it has two mirror image forms (enantiomers) that differ in their 3D arrangement of atoms. The (S)-enantiomer is the active form of pregabalin and is responsible for its therapeutic effects. The 13C3 label indicates that three carbon atoms in the molecule have been replaced with their heavier isotope, carbon-13. This labeling is used for research purposes to trace the fate of the drug in biological systems, such as metabolism and distribution. Chemically, (S)-Pregabalin-13C3 belongs to a class of compounds called gabapentinoids, which interact with the alpha-2-delta subunit of voltage-gated calcium channels in the nervous system. This interaction reduces the release of neurotransmitters involved in pain signaling and neuronal excitability, leading to the drug's analgesic and anticonvulsant effects. In addition, pregabalin also binds to the GABA-A receptor, which is involved in anxiety regulation. (S)-Pregabalin-13C3 is typically administered orally and is rapidly absorbed in the gastrointestinal tract. The drug has a half-life of about 6 hours and is primarily excreted in the urine. Some common side effects of pregabalin include dizziness, drowsiness, and peripheral edema. It is important to note that pregabalin has the potential for abuse and dependence, particularly in individuals with a history of substance abuse. Therefore, it should be used with caution and under the guidance of a healthcare provider.