3-O-Methyl 6-Keto 17β-Estradiol-d2 17-O-Tetrahydropyran

3-O-Methyl 6-Keto 17β-Estradiol-d2 17-O-Tetrahydropyran, also known as 3-MeO-6-Keto-E2-d2-17-O-THP, is a synthetic estrogen derivative that is widely used in scientific research as a reference standard and as a tool for understanding the mechanisms of estrogen action. The compound is a deuterated derivative of 3-O-Methyl 6-Keto 17β-Estradiol, which is a potent estrogen agonist. Its chemical structure is similar to that of the natural hormone estradiol, but with the addition of a methyl group at the 3 position, a keto group at the 6 position, and a tetrahydropyran ring at the 17 position. These modifications enhance the compound's stability and potency, making it useful for a range of research applications. As an estrogen agonist, 3-MeO-6-Keto-E2-d2-17-O-THP binds to estrogen receptors in cells and activates a variety of downstream signaling pathways. These include the regulation of gene expression, cell proliferation, and differentiation, among others. The compound has been used in studies of breast cancer, osteoporosis, and other estrogen-related diseases, as well as in drug discovery efforts targeting estrogen receptors. In summary, 3-MeO-6-Keto-E2-d2-17-O-THP is a useful and versatile tool for studying the mechanisms of estrogen action and developing new therapies for estrogen-related diseases. Its unique chemical structure and potent activity make it a valuable resource for researchers in many fields.