2-Oxo Clopidogrel-d3

2-Oxo Clopidogrel-d3 is a deuterated form of the antiplatelet drug Clopidogrel. Clopidogrel is used to prevent blood clots in patients with a history of heart attack, stroke, or peripheral artery disease. It works by inhibiting the activation of platelets, which are small cells in the blood that form clots to stop bleeding. However, Clopidogrel is metabolized by the liver and can vary in effectiveness depending on individual metabolism. 2-Oxo Clopidogrel-d3 is a labeled form of Clopidogrel that contains deuterium, a stable isotope of hydrogen. The addition of deuterium makes it easier to track the drug's metabolism in the body, allowing for more accurate dosing and personalized treatment plans. Chemically, 2-Oxo Clopidogrel-d3 is a thienopyridine derivative and a prodrug that is converted in the liver to its active form, which irreversibly inhibits the P2Y12 receptor on platelets. The deuterated form has the same mechanism of action and pharmacokinetics as the non-deuterated form. In conclusion, 2-Oxo Clopidogrel-d3 is a useful tool for studying the metabolism and effectiveness of Clopidogrel in patients. It provides valuable chemical information that can aid in personalized treatment plans, ultimately leading to better patient outcomes.