2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride

2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride is a stable isotope-labeled derivative of the compound 2-Acetyl-3,4,5,6-tetrahydropyridine (2-ATP), also known as MPTP. MPTP is a neurotoxin that is known to selectively destroy dopaminergic neurons in the substantia nigra of the brain, leading to the development of Parkinson's disease-like symptoms. The labeled derivative, 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride, is commonly used in research studies involving the metabolism and pharmacokinetics of MPTP. It can be used as a tracer in mass spectrometry studies to track the uptake, distribution, and elimination of MPTP in biological samples. The stable isotope labeling allows for more accurate and sensitive analysis of MPTP and its metabolites in complex biological matrices. Chemically, 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride is a white to off-white crystalline powder that is soluble in water and ethanol. It has a molecular formula of C7H9NO.Cl and a molecular weight of 169.61 g/mol. The stable isotope labeling involves the substitution of two carbon atoms in the pyridine ring of MPTP with the stable carbon isotope, 13C, which has an atomic mass of 13. This labeling allows for the differentiation of MPTP and its metabolites from other compounds in biological samples during mass spectrometry analysis.