Mephenytoin-D8

Mephenytoin-D8 is a deuterated analogue of mephenytoin, a drug commonly used to treat certain types of seizures. The deuterium atoms in Mephenytoin-D8 are substituted for hydrogen atoms, which alters the mass of the molecule and can lead to differences in the pharmacokinetics and pharmacodynamics of the drug. Like mephenytoin, Mephenytoin-D8 is believed to work by blocking the spread of electrical activity in the brain, which can help to prevent seizures from occurring. It is typically administered orally and is metabolized by the liver, with the deuterium substitution potentially affecting the rate and pathways of metabolism. Mephenytoin-D8 is commonly used in research settings as a stable isotope-labeled internal standard for the quantification of mephenytoin levels in biological samples. This can be useful for determining the pharmacokinetic properties of the drug, as well as for studying drug interactions and potential side effects. The chemical structure of Mephenytoin-D8 is similar to that of mephenytoin, with the addition of eight deuterium atoms. Its molecular formula is C13H8D8N2O2, and it has a molecular weight of 244.34 g/mol. It is a white crystalline powder that is soluble in organic solvents but insoluble in water. Overall, Mephenytoin-D8 is a useful tool for researchers studying mephenytoin and its effects on the body. Its deuterium substitution can alter the way the drug is metabolized and excreted, providing valuable insights into its pharmacokinetics and pharmacodynamics.