2-[Bis(1,1,2,2,2-pentadeuterioethyl)amino]-N-(2,6-dimethylphenyl)acetamide-D10

2-[Bis(1,1,2,2,2-pentadeuterioethyl)amino]-N-(2,6-dimethylphenyl)acetamide-D10, also known as D10-DPA, is a deuterated analogue of N,N-bis(2,6-dimethylphenyl)-2-aminoacetamide, which is used in the synthesis of inhibitors of the enzyme transglutaminase 2. D10-DPA is a stable isotope-labelled compound that is commonly used in the field of pharmaceutical research, specifically in drug metabolism studies. The chemical structure of D10-DPA consists of a central acetamide group attached to a 2,6-dimethylphenyl ring and two bis(1,1,2,2,2-pentadeuterioethyl)amino groups. The deuterium atoms present in the molecule provide a unique signature that allows for the determination of metabolic pathways and the identification of drug metabolites through mass spectrometry. D10-DPA is typically used as an internal standard in quantitative analysis of drug metabolites in biological samples. It is also used in drug discovery research to study the metabolic fate of drugs and to identify potential drug-drug interactions. The deuterium-labelling of D10-DPA provides a distinct advantage over non-deuterated analogues, as it allows for more accurate and precise measurements of drug concentrations in biological samples. In summary, D10-DPA is a valuable tool in drug metabolism studies and pharmaceutical research, providing a unique signature that allows for accurate and precise measurements of drug concentrations in biological samples.